Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA
نویسندگان
چکیده
منابع مشابه
Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA.
Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2011
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c1cc14706d